CYANOCOBALAMIN (vitamin B12)
Ọdịdị na Njirimara
Ngwaahịa a bụ ntụ kristal crystalline ma ọ bụ kristal, ọ naghị esi isi, ọ naghị atọ ụtọ ma nwee ike ịkpalite mmiri mmiri. Ọ na-agbaze ntakịrị na mmiri ma ọ bụ ethanol, ọ naghị agbaze na chloroform ma ọ bụ ether. Ọ na-eguzogide okpomọkụ, mana ọ nwere ike ọ gaghị arụ ọrụ mgbe a na-ekpughe ya na ihe ndị na-eme ka oxidation ma ọ bụ belata, nnu ígwè dị arọ na asịd siri ike na alkali siri ike.
Nhazi Kemịkalụ
Vitamin B12 bụ ihe mejupụtara equioctaphedral nke nwere ion cobalt. Nhazi etiti ya bụ mgbanaka corrin dị larịị nke nwere pyrroles anọ jikọtara ọnụ. Mkpụrụ ndụ vitamin B12 nwere ihe dị ka akụkụ atọ: mgbanaka gourin nke atọm N anọ na ion cobalt etiti jikọtara ọnụ; 5,6-dimethylbenzimidazole jikọtara na atọm N-7 na ion cobalt dị ka molekul vitamin B 12 nke ligands dị ala. Na mgbakwunye, DMBI jikọtara na aminopropanol site na otu phosphate, aminopropanol jikọtara ọnụ na usoro akụkụ propionic acid na pyrrole D; otu adenosyl ma ọ bụ otu methyl. Ọ na-ejikọ na ion cobalt iji mepụta ligand elu nke molekul vitamin B12.
Ọrụ Ahụ́ Ike
Enweghị vitamin B12 nwere ike ibute neuritis nke akụkụ ahụ. Ihe mbụ nke enweghị vitamin B12 na ụmụaka bụ ọnọdụ uche na-adịghị mma, ngosipụta nwayọ nwayọ, mmeghachi omume nwayọ nwayọ, ma mechaa bute anaemia. Na-akwalite mmepe na ntozu okè nke mkpụrụ ndụ ọbara uhie. A na-agbanwe Methylpropandiyl coenzyme A ka ọ bụrụ succinoyl coenzyme A ma na-esonye na okirikiri tricarboxylic acid, nke succinyl coenzyme A na-ejikọta ya na mmepụta nke heme. Vitamin B12 na-esonyekwa na mmepụta nke deoxynucleic acid (DNA), metabolism nke abụba, carbohydrates na protein, ma na-eme ka mmepụta nke nucleic acid na protein dịkwuo elu.
